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EEDFP Research Project

A hub for all research pertaining to Eco-Evolutionary Dynamics of Fluctuating Populations

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Experimental Work

Adaptation to the fitness costs of antibiotic resistance in Escherichia coli

7th February 2023 by Matthew Asker

Abstract: Policies aimed at alleviating the growing problem of drug-resistant pathogens by restricting antimicrobial usage implicitly assume that resistance reduces the Darwinian fitness of pathogens in the absence of drugs. While fitness costs have been … Read more

Categories Experimental Work, Relevant Papers

Potential for adaptation overrides cost of resistance

7th September 2022 by Mauro Mobilia

URL: https://doi.org/10.2217/fmb.15.61 Authors: Jorge Moura de Sousa, Ana Sousa, Catarina Bourgard, and Isabel Gordo Journal Ref.: Future Microbiol. 10, 1415-1431 (2015). Aim: To investigate the cost of antibiotic resistance versus the potential for resistant clones … Read more

Categories Experimental Work, Relevant Papers

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

7th September 2022 by Mauro Mobilia

URL: https://www.nature.com/articles/nrg3922 Authors: Diarmaid Hughes and Dan I. Andersson Journal Ref.: Nature Reviews Genetics 16, 459–471 (2015). Abstract: Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan infections, as … Read more

Categories Experimental Work, Relevant Papers

Social interaction in synthetic and natural microbial communities

7th September 2022 by Mauro Mobilia

URL: https://www.embopress.org/doi/full/10.1038/msb.2011.16 Author: Joao B Xavier Journal Ref.: Molecular Systems Biology 7, 483 (2011). Abstract: Social interaction among cells is essential for multicellular complexity. But how do molecular networks within individual cells confer the ability … Read more

Categories Experimental Work, Relevant Papers

Cooperation and Hamilton’s rule in a simple synthetic microbial system

7th September 2022 by Mauro Mobilia

URL: https://doi.org/10.1038/msb.2010.57 Authors: John S Chuang, Olivier Rivoire, and Stanislas Leibler Journal Ref.: Molecular Systems Biology 6, 398 (2010). Abstract: A fundamental problem in biology is understanding the evolutionary emergence and maintenance of altruistic behaviors. … Read more

Categories Experimental Work, Relevant Papers

Antibiotic-induced population fluctuations and stochastic clearance of bacteria

7th September 2022 by Mauro Mobilia

URL: https://doi.org/10.7554/eLife.32976 Authors: Jessica Coates, Bo Ryoung Park, Dai Le, Emrah Şimşek, Waqas Chaudhry, and Minsu Kim Journal Ref.: eLife 7:e32976 (2018). Abstract: Effective antibiotic use that minimizes treatment failures remains a challenge. A better … Read more

Categories Experimental Work, Relevant Papers

Feedback between Population and Evolutionary Dynamics Determines the Fate of Social Microbial Populations

8th August 2022 by Matthew Asker

Abstract: The evolutionary spread of cheater strategies can destabilize populations engaging in social cooperative behaviors, thus demonstrating that evolutionary changes can have profound implications for population dynamics. At the same time, the relative fitness of … Read more

Categories Experimental Work, Relevant Papers, Well-mixed models

Simpson’s Paradox in a Synthetic Microbial System

8th August 202225th April 2022 by Matthew Asker

Abstract: The maintenance of “public” or “common good” producers is a major question in the evolution of cooperation. Because nonproducers benefit from the shared resource without bearing its cost of production, they may proliferate faster … Read more

Categories Experimental Work, Relevant Papers, Spatial models
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  • About
  • Relevant Papers
    • Spatial models
    • Well-mixed models
    • Experimental Work
  • Code
  • Seminars & Talks
  • Publications & Preprints
  • People